Pattern of failure in prostate cancer previously treated with radical prostatectomy and post-operative radiotherapy: a secondary analysis of two prospective studies using novel molecular imaging techniques.

ABSTRACT:

Background

Prostate Membrane Specific Antigen (PSMA) positron emission tomography (PET) and multiparametric MRI (mpMRI) have shown high accuracy in identifying recurrent lesions after definitive treatment in prostate cancer (PCa). In this study, we aimed to outline patterns of failure in a group of post-prostatectomy patients who received adjuvant or salvage radiation therapy (PORT) and subsequently experienced biochemical recurrence, using ¹⁸F-PSMA PET/CT and mpMRI.

Methods

PCa patients with biochemical failure post-prostatectomy, and no evident site of recurrence on conventional imaging, were enrolled on two prospective trials of first and second generation ¹⁸F-PSMA PET agents (¹⁸F-DCFBC and ¹⁸F-DCFPyL) in combination with MRI be

SUBMITTER: Rowe LS 

PROVIDER: S-EPMC7874470 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature