Endothelial S1P₁ Signaling Counteracts Infarct Expansion in Ischemic Stroke.

ABSTRACT:

Rationale

Cerebrovascular function is critical for brain health, and endogenous vascular protective pathways may provide therapeutic targets for neurological disorders. S1P (Sphingosine 1-phosphate) signaling coordinates vascular functions in other organs, and S1P₁ (S1P receptor-1) modulators including fingolimod show promise for the treatment of ischemic and hemorrhagic stroke. However, S1P₁ also coordinates lymphocyte trafficking, and lymphocytes are currently viewed as the principal therapeutic target for S1P₁ modulation in stroke.

Objective

To address roles and mechanisms of engagement of endothelial cell S1P₁ in the naive and ischemic brain and its potential as a target for cerebrovascular therapy.

Methods and results

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SUBMITTER: Nitzsche A 

PROVIDER: S-EPMC7874503 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature