Toxic stress-specific cytoprotective responses regulate learned behavioral decisions in C. elegans.

ABSTRACT:

Background

Recognition of stress and mobilization of adequate "fight-or-flight" responses is key for survival and health. Previous studies have shown that exposure of Caenorhabditis elegans to pathogens or toxins simultaneously stimulates cellular stress and detoxification responses and aversive behavior. However, whether a coordinated regulation exists between cytoprotective stress responses and behavioral defenses remains unclear.

Results

Here, we show that exposure of C. elegans to high concentrations of naturally attractive food-derived odors, benzaldehyde and diacetyl, induces toxicity and food avoidance behavior. Benzaldehyde preconditioning activates systemic cytoprotective stress responses involving DAF-16/FOXO, SKN-1/Nrf2, and Hsp90 in non-neuronal cells, which conf

SUBMITTER: Hajdu G 

PROVIDER: S-EPMC7874617 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature