Isolation and Characterization of a Phage to Control Vancomycin Resistant Enterococcus Faecium.

ABSTRACT: Enterococcus faecium, is an important nosocomial pathogen with increased incidence of multidrug resistance (MDR) - specifically Vancomycin resistance. E. faecium constitutes the normal microbiota of the human intestine as well as exists in the hospitals and sewage, thus making the microorganism difficult to eliminate. Phage therapy has gained attention for controlling bacterial MDR infections and contaminations. We have successfully isolated from waste water and characterized a lytic bacteriophage STH1 capable of targeting Vancomycin resistant Enterococcus faecium (VREF) with high specificity. The phage was isolated from sewage water of a hospital at district Dera Ismail Khan, Pakistan. Initial characterization showed that magnesium and calcium ions significantly incre

SUBMITTER: Raza T 

PROVIDER: S-EPMC7874677 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature