A hyperacute immune map of ischaemic stroke patients reveals alterations to circulating innate and adaptive cells.

ABSTRACT: Systemic immune changes following ischaemic stroke are associated with increased susceptibility to infection and poor patient outcome due to their role in exacerbating the ischaemic injury and long-term disability. Alterations to the abundance or function of almost all components of the immune system post-stroke have been identified, including lymphocytes, monocytes and granulocytes. However, subsequent infections have often confounded the identification of stroke-specific effects. Global understanding of very early changes to systemic immunity is critical to identify immune targets to improve clinical outcome. To this end, we performed a small, prospective, observational study in stroke patients with immunophenotyping at a hyperacute time point (< 3 h) to explore early changes to circulat

SUBMITTER: Krishnan S 

PROVIDER: S-EPMC7874838 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature