Evaluation of PSEN1 subunit of the γ-secretase gene in patients with psoriasis vulgaris: a pilot study.

ABSTRACT:

Introduction

Psoriasis is a chronic autoimmune inflammatory disease, the prevalence of which is 1-3% in the Polish population. Genome testing using single nucleotide polymorphisms revealed more than 50 regions associated with the risk of psoriasis, and most of these genes are associated with the immune system.

Aim

To assess the presence of PSEN1 subunits of the γ-secretase gene polymorphisms in patients with psoriasis and comparison of results with a healthy control group.

Material and methods

We used polymerase chain reaction - restriction fragment length polymorphism (PCR RFLP) method to assess polymorphisms. The starting material for analysis was peripheral blood obtained from the patient.

Results

PSEN1a-positivity was found in 2/52 (2.78%) of patients with

SUBMITTER: Bergler-Czop B 

PROVIDER: S-EPMC7874871 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature