EIF2α controls memory consolidation via excitatory and somatostatin neurons.

ABSTRACT: An important tenet of learning and memory is the notion of a molecular switch that promotes the formation of long-term memory^1-4. The regulation of proteostasis is a critical and rate-limiting step in the consolidation of new memories^5-10. One of the most effective and prevalent ways to enhance memory is by regulating the synthesis of proteins controlled by the translation initiation factor eIF2¹¹. Phosphorylation of the α-subunit of eIF2 (p-eIF2α), the central component of the integrated stress response (ISR), impairs long-term memory formation in rodents and birds^11-13. By contrast, inhibiting the ISR by mutating the eIF2α phosphorylation site, genetically¹¹ and pharmacologically inhibiting the ISR kinases^14-17, or mimicki

SUBMITTER: Sharma V 

PROVIDER: S-EPMC7874887 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature