False-negative RT-PCR for COVID-19 and a diagnostic risk score: a retrospective cohort study among patients admitted to hospital.

ABSTRACT:

Objective

To describe the characteristics and outcomes of patients with a clinical diagnosis of COVID-19 and false-negative SARS-CoV-2 reverse transcription-PCR (RT-PCR), and develop and internally validate a diagnostic risk score to predict risk of COVID-19 (including RT-PCR-negative COVID-19) among medical admissions.

Design

Retrospective cohort study.

Setting

Two hospitals within an acute NHS Trust in London, UK.

Participants

All patients admitted to medical wards between 2 March and 3 May 2020.

Outcomes

Main outcomes were diagnosis of COVID-19, SARS-CoV-2 RT-PCR results, sensitivity of SARS-CoV-2 RT-PCR and mortality during hospital admission. For the diagnostic risk score, we report discrimination, calibration and diagnostic accuracy of the model an

SUBMITTER: Gupta-Wright A 

PROVIDER: S-EPMC7874904 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature