Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19.

ABSTRACT: COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response variation to disease severity and outcome over time, we longitudinally assessed circulating proteins as well as 188 surface protein markers, transcriptome, and T cell receptor sequence simultaneously in single peripheral immune cells from COVID-19 patients. Conditional-independence network analysis revealed primary correlates of disease severity, including gene expression signatures of apoptosis in plasmacytoid dendritic cells and attenuated inflammation but increased fatty acid metabolism in CD56^dimCD16^hi NK cells linked positively to circulating interleukin (IL)-15. CD8⁺ T cell activation was apparent without signs of exhaustion. Although cellular inflammation was depres

SUBMITTER: Liu C 

PROVIDER: S-EPMC7874909 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature