Identification of Key Modules and Hub Genes of Annulus Fibrosus in Intervertebral Disc Degeneration.

ABSTRACT: Background: Intervertebral disc degeneration impairs the quality of patients lives. Even though there has been development of many therapeutic strategies, most of them remain unsatisfactory due to the limited understanding of the mechanisms that underlie the intervertebral disc degeneration. Questions/purposes: This study is meant to identify the key modules and hub genes related to the annulus fibrosus in intervertebral disc degeneration (IDD) through: (1) constructing a weighted gene co-expression network; (2) identifying key modules and hub genes; (3) verifying the relationships of key modules and hub genes with IDD; and (4) confirming the expression pattern of hub genes in clinical samples. Methods: The Gene Expression Omnibus provided 24 sets of annulus fibrosus m

SUBMITTER: Wang H 

PROVIDER: S-EPMC7875098 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature