The Role of Mediobasal Hypothalamic PACAP in the Control of Body Weight and Metabolism.

ABSTRACT: Body energy homeostasis results from balancing energy intake and energy expenditure. Central nervous system administration of pituitary adenylate cyclase activating polypeptide (PACAP) dramatically alters metabolic function, but the physiologic mechanism of this neuropeptide remains poorly defined. PACAP is expressed in the mediobasal hypothalamus (MBH), a brain area essential for energy balance. Ventromedial hypothalamic nucleus (VMN) neurons contain, by far, the largest and most dense population of PACAP in the medial hypothalamus. This region is involved in coordinating the sympathetic nervous system in response to metabolic cues in order to re-establish energy homeostasis. Additionally, the metabolic cue of leptin signaling in the VMN regulates PACAP expression. We hypothesized that PA

SUBMITTER: Bozadjieva-Kramer N 

PROVIDER: S-EPMC7875177 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature