A Large-Scale, Stratified Genetic Analysis of the Major Histocompatibility Complex Region in Early- and Late-Onset Psoriasis in China.

ABSTRACT:

Background

Psoriasis vulgaris is a chronic inflammatory skin disease which occur at any age. It can be clinically classified into two age-onset subtypes: early-onset psoriasis (EOP; <40 years) and late-onset psoriasis (LOP; ≥40 years). More evidence showed EOP and LOP have different genetic architecture, notably the risk allele human leukocyte antigen (HLA)-C^*06:02 located within the major histocompatibility complex (MHC) region, which was reported to be the outstanding variant associated with EOP. However, genetic structure of EOP and LOP have not been fully elucidated.

Objective

To investigated HLA genetic heterogeneity between EOP and LOP in China.

Methods

We first calculated the MHC-based heritability of EOP and LOP respectively. Then, we conducted a la

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7875217 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature