Different human resting memory CD4⁺ T cell subsets show similar low inducibility of latent HIV-1 proviruses.

ABSTRACT: The latent reservoir of HIV-1 in resting CD4⁺ T cells is a major barrier to cure. It is unclear whether the latent reservoir resides principally in particular subsets of CD4⁺ T cells, a finding that would have implications for understanding its stability and developing curative therapies. Recent work has shown that proliferation of HIV-1-infected CD4⁺ T cells is a major factor in the generation and persistence of the latent reservoir and that latently infected T cells that have clonally expanded in vivo can proliferate in vitro without producing virions. In certain CD4⁺ memory T cell subsets, the provirus may be in a deeper state of latency, allowing the cell to proliferate without producing viral proteins, thus permitting escape from immune clea

SUBMITTER: Kwon KJ 

PROVIDER: S-EPMC7875249 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature