Circadian Pattern of Ion Channel Gene Expression in Failing Human Hearts.

ABSTRACT:

Background

Ventricular tachyarrhythmias and sudden cardiac death show a circadian pattern of occurrence in patients with heart failure. In the rodent ventricle, a significant portion of genes, including some ion channels, shows a circadian pattern of expression. However, genes that define electrophysiological properties in failing human heart ventricles have not been examined for a circadian expression pattern.

Methods

Ventricular tissue samples were collected from patients at the time of cardiac transplantation. Two sets of samples (n=37 and 46, one set with a greater arrhythmic history) were selected to generate pseudo-time series according to their collection time. A third set (n=27) of samples was acquired from the nonfailing ventricles of brain-dead donors. The expressi

SUBMITTER: McTiernan CF 

PROVIDER: S-EPMC7875252 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature