One-carbon metabolism-related micronutrients intake and risk for hepatocellular carcinoma: A prospective cohort study.

ABSTRACT: Deficient intake of micronutrients involved in one-carbon metabolism (eg, choline, methionine, vitamin B₁₂ and folic acid) leads to hepatocellular carcinoma (HCC) development in rodents, but is under-investigated in humans. We investigated the association between one-carbon metabolism-related micronutrient intake and HCC risk in a prospective cohort of 494 860 participants with 16 years of follow-up in the NIH-AARP study. Dietary intakes and supplement use were ascertained at baseline using a food-frequency questionnaire. Total intake (diet plus supplements) of the following one-carbon metabolism-related micronutrients were calculated: folate, methionine and vitamins B₂ (riboflavin), B₃ (niacin), B₆ and B₁₂ . These micronutrients were

SUBMITTER: Antwi SO 

PROVIDER: S-EPMC7875463 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature