Immune receptor inhibition through enforced phosphatase recruitment.

ABSTRACT: Antibodies that antagonize extracellular receptor-ligand interactions are used as therapeutic agents for many diseases to inhibit signalling by cell-surface receptors¹. However, this approach does not directly prevent intracellular signalling, such as through tonic or sustained signalling after ligand engagement. Here we present an alternative approach for attenuating cell-surface receptor signalling, termed receptor inhibition by phosphatase recruitment (RIPR). This approach compels cis-ligation of cell-surface receptors containing ITAM, ITIM or ITSM tyrosine phosphorylation motifs to the promiscuous cell-surface phosphatase CD45^2,3, which results in the direct intracellular dephosphorylation of tyrosine residues on the receptor target. As an example, we found that t

SUBMITTER: Fernandes RA 

PROVIDER: S-EPMC7875542 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature