Bile acids during pregnancy: Trimester variations and associations with glucose homeostasis.

ABSTRACT:

Background and aims

Bile acids are known to contribute to hepatic glucose and lipid metabolism regulation. Although glucose homeostasis sustains well-characterized modifications during uncomplicated pregnancies, changes in bile acids concentrations and relative proportions throughout pregnancy remain unknown. Furthermore, literature shows strong associations between bile acids profiles and glucose homeostasis under normal metabolic conditions. We seek, first, to characterize bile acids' metabolic changes across trimesters and, second, to evaluate associations between changes in bile acids and glucose homeostasis indexes in the first and second trimesters.

Methods

A total of 78 women were recruited and followed at each trimester of pregnancy. Fasting serum samples were collec

SUBMITTER: Gagnon M 

PROVIDER: S-EPMC7875570 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature