Lead exposure and association with angiogenic factors and hypertensive disorders of pregnancy.

ABSTRACT:

Objectives

Lead exposure has been associated with hypertensive disorders of pregnancy. Angiogenic factors, including soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PlGF), are aberrant in preeclampsia, but have not been correlated with lead levels. We evaluated the association of lead exposure with angiogenic factors.

Study design

This cross sectional study utilized a convenience sample of singleton pregnancies ≥34 weeks' gestation. Blood lead and angiogenic factors were measured before delivery; bone lead was measured postpartum. We dichotomized bone and blood lead into the top tertile versus the bottom tertiles and used log-binomial regression to assess the association between lead and a high angiogenic ratio.

Main outcome measures

The outcom

SUBMITTER: Johnson KM 

PROVIDER: S-EPMC7875573 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature