Imputation of Ordinal Outcomes: A Comparison of Approaches in Traumatic Brain Injury.

ABSTRACT: Loss to follow-up and missing outcomes data are important issues for longitudinal observational studies and clinical trials in traumatic brain injury. One popular solution to missing 6-month outcomes has been to use the last observation carried forward (LOCF). The purpose of the current study was to compare the performance of model-based single-imputation methods with that of the LOCF approach. We hypothesized that model-based methods would perform better as they potentially make better use of available outcome data. The Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study (n = 4509) included longitudinal outcome collection at 2 weeks, 3 months, 6 months, and 12 months post-injury; a total of 8185 Glasgow Outcome Scale extended (GOSe

SUBMITTER: Kunzmann K 

PROVIDER: S-EPMC7875604 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature