Accelerated Failure Time Survival Model to Analyze Morris Water Maze Latency Data.

ABSTRACT: Traumatic brain injury (TBI) induces cognitive deficits clinically and in animal models. Learning and memory testing is critical when evaluating potential therapeutic strategies and treatments to manage the effects of TBI. We evaluated three data analysis methods for the Morris water maze (MWM), a learning and memory assessment widely used in the neurotrauma field, to determine which statistical tool is optimal for MWM data. Hidden platform spatial MWM data aggregated from three separate experiments from the same laboratory were analyzed using 1) a logistic regression model, 2) an analysis of variance (ANOVA) model, and 3) an accelerated failure time (AFT) time-to-event model. The logistic regression model showed no significant evidence of differences between treatments among any swims ove

SUBMITTER: Andersen CR 

PROVIDER: S-EPMC7875609 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature