Validation of the Role of Thrombin Generation Potential by a Fully Automated System in the Identification of Breast Cancer Patients at High Risk of Disease Recurrence.

ABSTRACT: Background  The measurement of thrombin generation (TG) potential by the calibrated automated thrombogram (CAT) assay provides a strong contribution in identifying patients at high risk of early disease recurrence (E-DR). However, CAT assay still needs standardization and clinical validation. Objective  In this study, we aimed to validate the role of TG for E-DR prediction by means of the fully automated ST Genesia system. Methods  A prospective cohort of 522 patients from the HYPERCAN study with newly diagnosed resected high-risk breast cancer was included. Fifty-two healthy women acted as controls. Plasma samples were tested for protein C, free-protein S, and TG by ST Genesia by using the STG-ThromboScreen reagent with and without thrombomodulin (TM). Results

SUBMITTER: Gomez-Rosas P 

PROVIDER: S-EPMC7875677 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature