Compositional Variability and Mutation Spectra of Monophyletic SARS-CoV-2 Clades.

ABSTRACT: COVID-19 and its causative pathogen SARS-CoV-2 have rushed the world into a staggering pandemic in a few months, and a global fight against both has been intensifying. Here, we describe an analysis procedure where genome composition and its variables are related, through the genetic code to molecular mechanisms, based on understanding of RNA replication and its feedback loop from mutation to viral proteome sequence fraternity including effective sites on the replicase-transcriptase complex. Our analysis starts with primary sequence information, identity-based phylogeny based on 22,051 SARS-CoV-2 sequences, and evaluation of sequence variation patterns as mutation spectra and its 12 permutations among organized clades. All are tailored to two key mechanisms: strand-biased and function-assoc

SUBMITTER: Teng X 

PROVIDER: S-EPMC7875716 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature