Construction of co-expression modules related to survival by WGCNA and identification of potential prognostic biomarkers in glioblastoma.

ABSTRACT: Glioblastoma (GBM) is a malignant brain tumour with poor prognosis. The potential pathogenesis and therapeutic target are still need to be explored. Herein, TCGA expression profile data and clinical information were downloaded, and the WGCNA was conducted. Hub genes which closely related to poor prognosis of GBM were obtained. Further, the relationship between the genes of interest and prognosis of GBM, and immune microenvironment were analysed. Patients from TCGA were divided into high- and low-risk group. WGCNA was applied to the high- and low-risk group and the black module with the lowest preservation was identified which could distinguish the prognosis level of these two groups. The top 10 hub genes which were closely related to poor prognosis of patients were obtained. GO analysis sh

SUBMITTER: Zhou J 

PROVIDER: S-EPMC7875936 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature