Systemic Lupus Erythematosus in Children and Young People.

ABSTRACT:

Purpose of review

Juvenile-onset systemic lupus erythematosus ((j)SLE) is an autoimmune/inflammatory disease that results in significant damage and disability. When compared to patients with disease onset in adulthood, jSLE patients exhibit increased disease activity, damage and require more aggressive treatments. This manuscript summarises age-specific pathogenic mechanisms and underscores the need for age group-specific research, classification and treatment.

Recent findings

Genetic factors play a significant role in the pathophysiology of jSLE, as > 7% of patients develop disease as a result of single gene mutations. Remaining patients carry genetic variants that are necessary for disease development, but require additional factors. Increased 'genetic impact' likely contr

SUBMITTER: Charras A 

PROVIDER: S-EPMC7875946 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature