Integrative analysis identifies bHLH transcription factors as contributors to Parkinson's disease risk mechanisms.

ABSTRACT: Genome-wide association studies (GWAS) have identified multiple genetic risk signals for Parkinson's disease (PD), however translation into underlying biological mechanisms remains scarce. Genomic functional annotations of neurons provide new resources that may be integrated into analyses of GWAS findings. Altered transcription factor binding plays an important role in human diseases. Insight into transcriptional networks involved in PD risk mechanisms may thus improve our understanding of pathogenesis. We analysed overlap between genome-wide association signals in PD and open chromatin in neurons across multiple brain regions, finding a significant enrichment in the superior temporal cortex. The involvement of transcriptional networks was explored in neurons of the superior temporal corte

SUBMITTER: Berge-Seidl V 

PROVIDER: S-EPMC7875985 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature