Combined quantum tunnelling and dielectrophoretic trapping for molecular analysis at ultra-low analyte concentrations.

ABSTRACT: Quantum tunnelling offers a unique opportunity to study nanoscale objects with atomic resolution using electrical readout. However, practical implementation is impeded by the lack of simple, stable probes, that are required for successful operation. Existing platforms offer low throughput and operate in a limited range of analyte concentrations, as there is no active control to transport molecules to the sensor. We report on a standalone tunnelling probe based on double-barrelled capillary nanoelectrodes that do not require a conductive substrate to operate unlike other techniques, such as scanning tunnelling microscopy. These probes can be used to efficiently operate in solution environments and detect single molecules, including mononucleotides, oligonucleotides, and proteins. The probes

SUBMITTER: Tang L 

PROVIDER: S-EPMC7876030 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature