Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8⁺ T Cells.

ABSTRACT: The antigen-independent, strong proliferative responses of naive CD8⁺ T cells have been well demonstrated in a particular strain of mice lacking IL-2 receptors. This type of proliferation is mainly driven by common gamma-chain (γ_c) cytokines, such as IL-2, IL-7, and IL-15, present at abnormally high levels in these mice. Similarly, in the present study, we showed that mice lacking Janus kinase 3 (Jak3), a tyrosine kinase crucial for γ_c cytokine signaling, could induce strong proliferation of adoptively transferred naive CD8⁺ T cells. This proliferation was also independent of antigenic stimulation, but heavily dependent on IL-2, as evidenced by the failure of proliferation of adoptively transferred IL-2 receptor alpha- and beta-chain-deficient na

SUBMITTER: Lee GW 

PROVIDER: S-EPMC7876067 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature