Origami paper analytical assay based on metal complex sensor for rapid determination of blood cyanide concentration in fire survivors.

ABSTRACT: Cyanide-based blood poisoning can seriously damage fire victims and cause death if not detected quickly. Previous conventional methods require laboratory equipment, which are expensive and increase the duration of the analysis. Here, a simple origami based microfluidic device was introduced for point of need detection of blood cyanide concentration in people involved in fire. The device is made of four layers of paper. Each layer was in the size of 1 × 1 cm folded on each other. In this work, the blood sample was acidified by trichloroacetic acid to separate cyanide from methaemoglobin in the form of HCN gas. The produced gas released into borate buffer to recover free cyanide ions which interacted with the Pt complex ([Pt(p-MeC₆H₄)₂(phen)]) used as a recep

SUBMITTER: Sheini A 

PROVIDER: S-EPMC7876125 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature