IL-21-Deficient T Follicular Helper Cells Support B Cell Responses Through IL-27 in Patients With Chronic Hepatitis B.

ABSTRACT: Chronic Hepatitis B (CHB) affects over 350 million people worldwide. Current treatment does result in reduced complications; however, a cure (development of antibodies to the S antigen) is not achieved, requiring life-long therapy. Humoral responses contribute to viral elimination by secreting neutralizing antibodies; though, effective induction of humoral immunity require CD4T cell differentiation into T follicular helper (T_FH) cells that support B cell response through interleukin-21 (IL-21). In CHB, mechanism of T_FH-B interactions is seldom described. During CHB, T_FH cells are defective in producing IL-21 in response to hepatitis B surface antigen (HBsAg). However, regardless of low IL-21, T_FH cells efficiently support B cell responses by prod

SUBMITTER: Khanam A 

PROVIDER: S-EPMC7876309 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature