Proteomic Characterization of Human Neural Stem Cells and Their Secretome During in vitro Differentiation.

ABSTRACT: Cell therapies represent a promising approach to slow down the progression of currently untreatable neurodegenerative diseases (e.g., Alzheimer's and Parkinson's disease or amyotrophic lateral sclerosis), as well as to support the reconstruction of functional neural circuits after spinal cord injuries. In such therapies, the grafted cells could either functionally integrate into the damaged tissue, partially replacing dead or damaged cells, modulate inflammatory reaction, reduce tissue damage, or support neuronal survival by secretion of cytokines, growth, and trophic factors. Comprehensive characterization of cells and their proliferative potential, differentiation status, and population purity before transplantation is crucial to preventing safety risks, e.g., a tumorous growth due to th

SUBMITTER: Cervenka J 

PROVIDER: S-EPMC7876319 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature