Modeling Cell Energy Metabolism as Weighted Networks of Non-autonomous Oscillators.

ABSTRACT: Networks of oscillating processes are a common occurrence in living systems. This is as true as anywhere in the energy metabolism of individual cells. Exchanges of molecules and common regulation operate throughout the metabolic processes of glycolysis and oxidative phosphorylation, making the consideration of each of these as a network a natural step. Oscillations are similarly ubiquitous within these processes, and the frequencies of these oscillations are never truly constant. These features make this system an ideal example with which to discuss an alternative approach to modeling living systems, which focuses on their thermodynamically open, oscillating, non-linear and non-autonomous nature. We implement this approach in developing a model of non-autonomous Kuramoto oscillators in two

SUBMITTER: Rowland Adams J 

PROVIDER: S-EPMC7876325 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature