Pan-Cancer Molecular Characterization of m⁶A Regulators and Immunogenomic Perspective on the Tumor Microenvironment.

ABSTRACT:

Purpose

N6-methyladenosine (m⁶A) methylation plays a critical role in diverse biological processes. However, knowledge regarding the constitution of m⁶A on tumor microenvironment (TME) and tumor-infiltrating lymphocytes (TILs) across cancer types is still lacking. We performed comprehensive immuno-genomic analyses to reveal molecular characterization of the m⁶A regulators and immune-related genes (IRGs) across TME and TIL heterogeneity.

Methods

We comprehensively analyzed the properties of m⁶A regulators in genomic profiles from The Cancer Genome Atlas (TCGA) according to expression perturbations of crucial IRGs, CD274, CD8A, GZMA, and PRF1. The four IRGs were proved to be reliable biomarkers of TILs and TME via CIBERSORT an

SUBMITTER: Zhu J 

PROVIDER: S-EPMC7876474 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature