Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens.

ABSTRACT: Synthetic lethal screens are used to discover new combination treatments for cancer. In traditional high-throughput synthetic lethal screens, compounds are tested at a single dose, and hit selection is based on threshold activity values from the variance of the efficacy of the compounds tested. The limitation of the single-dose screening for synthetic lethal screens is that it does not allow for the robust detection of differential activities from compound collections with a broad range of potencies and efficacies. There is therefore a need to develop screening approaches that enable the identification of compounds with synthetic lethal effects based on changes in both potency and efficacy. Here we describe the implementation of a dose response-based synthetic lethal screen to find drugs t

SUBMITTER: Guha R 

PROVIDER: S-EPMC7876566 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature