Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study.

ABSTRACT:

Objective

To evaluate whether early initiation of prophylactic anticoagulation compared with no anticoagulation was associated with decreased risk of death among patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United States.

Design

Observational cohort study.

Setting

Nationwide cohort of patients receiving care in the Department of Veterans Affairs, a large integrated national healthcare system.

Participants

All 4297 patients admitted to hospital from 1 March to 31 July 2020 with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and without a history of anticoagulation.

Main outcome measures

The main outcome was 30 day mortality. Secondary outcomes were inpatient mortality, initiatin

SUBMITTER: Rentsch CT 

PROVIDER: S-EPMC7876672 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature