In silico analysis of phytochemicals as potential inhibitors of proteases involved in SARS-CoV-2 infection.

ABSTRACT: In silico analysis of six phytochemicals, flabelliferin, marmelosin, piperine, ocimin, curcumin and leucoanthocyanin, along with three drug compounds, nelfinavir, remdesivir and hydroxychloroquine, as positive control against drug targets of one SARS-CoV-2 viral protease, COVID-19 main protease (SARS CoV-2 3CL^pro/M^pro), two coronavirus proteases, SARS-CoV main peptidase (SARS CoV M^pro), SARS-CoV main proteinase (SARS CoV 3CL^pro), and one human cellular transmembrane serine proteinase (TMPRSS2), was carried out. Except leucoanthocyanin all other phytochemicals proved better than all three positive control drugs against SARS-CoV main peptidase, whereas, flabelliferin was found to be the potential inhibitor for SARS-CoV main proteinase out pe

SUBMITTER: Umadevi P 

PROVIDER: S-EPMC7876729 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature