Early anterior cingulate involvement is seen in presymptomatic MAPT P301L mutation carriers.

ABSTRACT:

Background

PET imaging of glucose metabolism has revealed presymptomatic abnormalities in genetic FTD but has not been explored in MAPT P301L mutation carriers. This study aimed to explore the patterns of presymptomatic hypometabolism and atrophy in MAPT P301L mutation carriers.

Methods

Eighteen asymptomatic members from five families with a P301L MAPT mutation were recruited to the study, six mutation carriers, and twelve mutation-negative controls. All participants underwent standard behavioural and cognitive assessment as well as [¹⁸F]FDG-PET and 3D T1-weighted MRI brain scans. Regional standardised uptake value ratios (SUVR) for the PET scan and volumes calculated from an automated segmentation for the MRI were obtained and compared between the mutation carrie

SUBMITTER: Clarke MTM 

PROVIDER: S-EPMC7876816 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature