Constitutive activation of NF-κB during early bone marrow development results in loss of B cells at the pro-B-cell stage.

ABSTRACT: There is a considerable body of work exploring the role of NF-κB family of transcription factors in the maturation and functions of later stage B cells; however, their role in the earlier bone marrow stages of development is less well understood despite the demonstration that NF-κB activity is present at all early stages of B-cell development. To explore the consequences of early, B cell-targeted constitutive activation of both NF-κB pathways on B-cell development, we generated mice that have either or both. NF-κB pathways constitutively activated beginning in early pro-B cells. In marked contrast to activating a single pathway, we found mice with both pathways constitutively activated displayed a profound loss of B cells, starting with early pro-B cells and peaking at the late pro-B-cell

SUBMITTER: Paun A 

PROVIDER: S-EPMC7876872 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature