Application of a unified probabilistic framework to the dose-response assessment of acrolein.

ABSTRACT:

Background

In quantitative chemical risk assessment, a reference value is an estimate of an exposure to a chemical that is "likely to be without appreciable risk." Because current "deterministic" approaches do not quantitatively characterize the likelihood or severity of harm, the National Academies has recommended using reference values derived from a risk-specific dose that are treated as random variables, with probability distributions characterizing uncertainty and variability.

Objectives

In order to build familiarity and address issues needed for routine and standardized derivation of probabilistic risk-specific dose distributions, a case example applying the unified probabilistic framework presented in Chiu and Slob (2015) is developed for acrolein. This case study is

SUBMITTER: Blessinger T 

PROVIDER: S-EPMC7877001 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature