Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT.

ABSTRACT: Curcumin, a phytochemical from rhizomes of the plant Curcuma longa, has been reported to exert potential anticancer properties in various cancer types, including acute myeloid leukemia (AML). However, the underlying mechanism remains poorly understood. The present study demonstrated that curcumin had a stronger cytotoxic activity against AML cells compared with three other types of phytochemicals (epigallocatechin gallate, genistein and resveratrol). Protein phosphorylation profiling using an antibody array identified that curcumin treatment increased the phosphorylation levels of 14 proteins and decreased those of four proteins. A protein‑protein interaction network was constructed using the STRING database, in which AKT was identified as a hub protein with the highest connectivity (PRAS4

SUBMITTER: Zhou H 

PROVIDER: S-EPMC7877002 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature