Left ventricular ejection fraction and right atrial diameter are associated with deep regional CBF in arteriosclerotic cerebral small vessel disease.

ABSTRACT:

Background

Systemic cardiac hypoperfusion is a well-acknowledged contributor to ischemic leukoencephalopathy. However, it has remained elusive how atherosclerosis-mediated cardiac remodelling modifies cerebral perfusion homeostasis as well as neuroimaging burden in cerebral small vessel disease (CSVD) development.

Methods

This retrospective study identified 103 arteriosclerotic CSVD (aCSVD) patients (CSVD burden^low 0 ~ 1, n = 61 and CSVD burden^high 2 ~ 4, n = 42) from Sep. 2017 to Dec. 2019 who underwent transthoracic echocardiography(n = 81), structural magnetic resonance imaging and arterial spin labelling (ASL). Total CSVD burden was graded according to the ordinal "small vessel disease" rating score (0-4). We investigated the univariate and multivar

SUBMITTER: Chen X 

PROVIDER: S-EPMC7877009 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature