The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization.

ABSTRACT:

Objective

Macrophages are a major component of the tumor microenvironment. M1 macrophages secrete pro-inflammatory factors that inhibit tumor growth and development, whereas tumor-associated macrophages (TAMs) mainly exhibit an M2 phenotype. Our previous studies have shown that the interleukin-33/ST2 (IL-33/ST2) axis is essential for activation of the M1 phenotype. This study investigates the role of the IL-33/ST2 axis in TAMs, its effects on tumor growth, and whether it participates in the mutual conversion between the M1 and M2 phenotypes.

Methods

Bone marrow-derived macrophages were extracted from wildtype, ST2 knockout (ST2^-/-), and Il33-overexpressing mice and differentiated with IL-4. The mitochondrial and lysosomal number and location, and the expression of

SUBMITTER: Xu H 

PROVIDER: S-EPMC7877183 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature