Mechanical cues protect against silica nanoparticle exposure in SH-SY5Y neuroblastoma.

ABSTRACT: The increasing appearance of engineered nanomaterials in broad biomedical and industrial sectors poses an escalating health concern from unintended exposure with unknown consequences. Routine in vitro assessments of nanomaterial toxicity are a vital component to addressing these mounting health concerns; however, despite the known role of cell-cell and cell-matrix contacts in governing cell survival, these physical interactions are generally ignored. Herein, we demonstrate that exposure to amorphous silica particles destabilizes mitochondrial membrane potential, stimulates reactive oxygen species (ROS) production and promotes cytotoxicity in SH-SY5Y human neuroblastoma through mechanisms that are potently matrix dependent, with SH-SY5Y cells plated on the softest matrix displaying a near c

SUBMITTER: Bell KJ 

PROVIDER: S-EPMC7877221 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature