LINC00494 Promotes Ovarian Cancer Development and Progression by Modulating NFκB1 and FBXO32.

ABSTRACT:

Background

Ovarian cancer represents one of the most frequent gynecological cancers and is significant cause of death for women around the world. Long non-coding RNAs (lncRNAs) are recognized as critical governors of gene expression during carcinogenesis, but their effects on the occurrence and development of ovarian cancer require further investigation. In this report, we characterized LINC00494 as a novel oncogenic lncRNA in ovarian cancer.

Methods

Bioinformatics analysis predicted potential interactions among LINC00494, NFκB1, and FBXO32 in ovarian cancer, which were tested by dual-luciferase reporter assay, RNA pull-down, RIP, and ChIP assay. Cancer cells were transfected with relevant treated plasmids, followed by scratch and Transwell assays. The treated cells were inj

SUBMITTER: Shu Y 

PROVIDER: S-EPMC7877250 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature