Class I histone deacetylase inhibition promotes CD8 T cell activation in ovarian cancer.

ABSTRACT:

Objective

Patients with epithelial ovarian cancer (EOC) typically present with late-stage disease, posing a significant challenge to treatment. Although taxane and platinum-based chemotherapy plus surgical debulking are initially effective, EOC is marked by frequent recurrence with resistant disease. Immunotherapy represents an appealing treatment paradigm given the ability of immune cells to engage metastatic sites and impede recurrence; however, response rates to checkpoint blockade in ovarian cancer have been disappointing. Here, we tested whether class I HDAC inhibition can promote anti-tumor T cell responses in a spontaneous and nonspontaneous murine model of EOC.

Methods

We used the spontaneous Tg-MISIIR-Tag and nonspontaneous ID8 models of murine ovarian cancer to tes

SUBMITTER: McCaw TR 

PROVIDER: S-EPMC7877343 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature