Psychiatric disorders in offspring of childhood or adolescent central nervous system tumor survivors: a national cohort study.

ABSTRACT:

Background

Children experience a higher risk of psychiatric problems when their parents are diagnosed with cancer. However, the psychological effect among offspring who are born after parental cancer diagnosed in childhood or adolescence is unknown. We aimed to investigate the risk of psychiatric disorders in children of survivors with childhood or adolescent central nervous system (CNS) tumors.

Methods

By combining several nationwide Swedish registers, we identified all children who had at least one parent previously diagnosed with CNS tumor below the age of 20. Five children without parental CNS tumor were randomly selected for the matching. Cox proportional hazards model was used to calculate hazard ratios (HRs) with 95% confidence interval (CI).

Results

The incide

SUBMITTER: Huang W 

PROVIDER: S-EPMC7877351 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature