Establishment and validation of a prognostic nomogram based on a novel five-DNA methylation signature for survival in endometrial cancer patients.

ABSTRACT:

Background

This study aimed to explore the prognostic role of DNA methylation pattern in endometrial cancer (EC) patients.

Methods

Differentially methylated genes (DMGs) of EC patients with distinct survival from The Cancer Genome Atlas (TCGA) database were analyzed to identify methylated genes as biomarkers for EC prognosis. The Least Absolute Shrinkage and Selection Operator (LASSO) analysis was used to construct a risk score model. A nomogram was built based on analysis combining the risk score model with clinicopathological signatures together, and then verified in the validation cohort and patients in our own center.

Results

In total, 157 DMGs were identified between different prognostic groups. Based on the LASSO analysis, five genes (GBP4, OR8K3, GABRA2, RIPPLY

SUBMITTER: Li X 

PROVIDER: S-EPMC7877372 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature