Reactivation-Dependent Amnesia for Contextual Fear Memories: Evidence for Publication Bias.

ABSTRACT: Research on memory reconsolidation has been booming in the last two decades, with numerous high-impact publications reporting promising amnestic interventions in rodents and humans. However, our own recently-published failed replication attempts of reactivation-dependent amnesia for fear memories in rats suggest that such amnestic effects are not always readily found and that they depend on subtle and possibly uncontrollable parameters. The discrepancy between our observations and published studies in rodents suggests that the literature in this field might be biased. The aim of the current study was to gauge the presence of publication bias in a well-delineated part of the reconsolidation literature. To this end, we performed a systematic review of the literature on reactivation-dependent

SUBMITTER: Schroyens N 

PROVIDER: S-EPMC7877470 | biostudies-literature | 2021 Jan-Feb

REPOSITORIES: biostudies-literature