Intravenous infusion of rocuronium bromide prolongs emergence from propofol anesthesia in rats.

ABSTRACT:

Background

Neuromuscular blocking agents induce muscle paralysis via the prevention of synaptic transmission at the neuromuscular junction and may have additional effects at other sites of action. With regard to potential effects of neuromuscular blocking agents on the central nervous system, a definitive view has not been established. We investigated whether intravenous infusion of rocuronium bromide affects the emergence from propofol anesthesia.

Methods

Using an in vivo rat model, we performed propofol infusion for 60 minutes, along with rocuronium bromide at various infusion rates or normal saline. Sugammadex or normal saline was injected at the end of the infusion period, and we evaluated the time to emergence from propofol anesthesia. We also examined the neuromuscular

SUBMITTER: Suzuki K 

PROVIDER: S-EPMC7877640 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature