Antivenomics and in vivo preclinical efficacy of six Latin American antivenoms towards south-western Colombian Bothrops asper lineage venoms.
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ABSTRACT:
SUBMITTER: Mora-Obando D
PROVIDER: S-EPMC7877754 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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Antivenomics and in vivo preclinical efficacy of six Latin American antivenoms towards south-western Colombian Bothrops asper lineage venoms.
Mora-Obando Diana D Pla Davinia D Lomonte Bruno B Guerrero-Vargas Jimmy Alexander JA Ayerbe Santiago S Calvete Juan J JJ
PLoS neglected tropical diseases 20210201 2
<h4>Background</h4>Bothrops asper represents the clinically most important snake species in Central America and Northern South America, where it is responsible for an estimated 50-80% of snakebites. Compositional variability among the venom proteomes of B. asper lineages across its wide range mirrors clinical differences in their envenomings. Bothropic antivenoms generated in a number of Latin American countries commonly exhibit a certain degree of paraspecific effectiveness in the neutralizatio ...[more]
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