Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis patient bioaerosols.

ABSTRACT: Interrupting transmission is an attractive anti-tuberculosis (TB) strategy but it remains underexplored owing to our poor understanding of the events surrounding transfer of Mycobacterium tuberculosis (Mtb) between hosts. Determining when live, infectious Mtb bacilli are released and by whom has proven especially challenging. Consequently, transmission chains are inferred only retrospectively, when new cases are diagnosed. This process, which relies on molecular analyses of Mtb isolates for epidemiological fingerprinting, is confounded by the prolonged infectious period of TB and the potential for transmission from transient exposures. We developed a Respiratory Aerosol Sampling Chamber (RASC) equipped with high-efficiency filtration and sampling technologies for liquid-capture of all part

SUBMITTER: Dinkele R 

PROVIDER: S-EPMC7877778 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature